Oral Presentation First Malaria World Congress 2018

The importance of preventing P. vivax relapse in Papuan children (#42)

Jeanne Rini Poespoprodjo 1
  1. Timika Research Facility - Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Timika, PAPUA, Indonesia

Background: In southern Papua, Indonesia, malaria is highly prevalent in young children and is a significant cause of morbidity and early mortality. The association between malaria and delayed mortality is unknown.

Methods: Routinely-collected hospital surveillance data from southern Papua, Indonesia, were used to assess the risk of recurrent malaria and mortality within 12 months of an initial presentation with malaria in all children younger than 5 years old attending the local hospital. Analysis was primarily by Kaplan Meier and Cox regression methods.

Results: In total 15,716 children presenting with malaria between April 2004 and December 2013 were included in the analysis; 6184 (39.3%) with P. falciparum, 7499 (47.7%) with P. vivax, 203 (1.3%) with P. malariae, 3 with P. ovale and 1827 (11.6%) with mixed infections. Within 1 year, 48.4% (7,620/15,716) of children represented a total of 16,957 times with malaria (range 1 to 11 episodes), with the incidence of malaria being greater in patients initial presenting with P. vivax infection (1334 [95%CI 1307-1361] per 1000 patient years) compared to those with P. falciparum infection (920 [896-944]). In total 266 (1.7%) children died within one year of their initial presentation, 129 (48.5%) within 30 days and 137 (51.5%) between 31 and 365 days. There was no significant difference in the mortality risk in patients infected with P. vivax versus P. falciparum after either 30 days (Hazard Ratio (HR) 1.06 [0.73,1.54]) or 365 days (HR= 1.30 [0.90,1.88]). Children who died had a greater incidence of malaria, 2280 [95%CI 1946-2671] per 1000 patient years preceding their death, compared to 1141 [95%CI 1124-1158] per 1000 patient years in those surviving.

Conclusions: Children under-five years old with P. vivax malaria, are at significant risk of multiple representations with malaria and of dying within one year of their initial presentation. Preventing recurrent malaria must be a public health priority in this vulnerable population.