Despite their ability to infect all stages of human blood cells, P. falciparum tend to show a propensity towards immature red blood cells, known as reticulocytes, for invasion. In the case of P.vivax, the second largest member of the family,only immature reticulocytes presenting transferrin receptor are recognised for invasion by the parasite. While surface proteins such as Duffy antigen that are found in abundance in reticulocytes could contribute to this unique preference, information on other possible host components involved in preferential invasion remain elusive. Reticulocytes comprise of approximately 2% of the red blood cell population and are predominantly found in bone marrow and cord blood and are constantly evolving, making it a difficult cell type to conduct large-scale experiments. Herein, we report the mass spectrometric data corresponding to cord blood-derived immature reticulocytes. In this study, we documented distinct global changes associated with reticulocyte maturation and its consequences during plasmodium infectionThese findings highlight the significance of studying the dynamics of host cell biochemistry and its dynamics, in the context of malaria infection, in order to target proteins for therapeutic interventions.