From May 2014 and April 2017, the METF opened 1222 Malaria Posts (MP), providing early diagnosis and treatment (EDT) to an estimated 365,000 persons; conducted 272 prevalence surveys; identified 69 hotspot villages; and conducted MDA in 61 hotspots. In 3 years, falciparum malaria incidence decreased by 75%. The main driver of this decrease was likely the generalized access to EDT at MP (25% decrease in incidence per 3-month period of activity). Hotspot villages exhibited a slower decrease, associated with higher incidence than neighbouring non-hotspot villages. MDA resulted in a 5-fold decrease in P. falciparum incidence after MDA compared to before, confirmed by a 90% reduction of the parasite reservoir persisting at least 12 months.