Global malaria burden has significantly declined chiefly due to the efficacious Artemisinin Combination Therapy (ACT). ACT had been deployed at Thai-Myanmar border since 1990's and was a principal determinant for malaria elimination. However, artemisinin resistance had emerged on the Thai-Cambodia border and now it is wide-spread in the Greater Mekhong Sub-region. The artemisinin resistance compounded on the existing mefloquine resistance on the Thai-Myanmar border, has led to the failure of the ACT compound. In Myanmar, the cure rate of ACT's are still high though continuing vigilance is necessary, as the K13 mutations associated with artemisinins resistance has reached the Myanmar-India/China border.