Michelle Wykes First Malaria World Congress 2018

Michelle Wykes

Michelle Wykes has been working on the pathogenesis of malaria for several years. Her research has shown how dendritic cell (DC) function is corrupted lethal malaria in a mouse model, by comparing 4 mouse parasite species. Further, she recently showed that this loss of DC function prevented the activation of memory B cells specific for the MSP1-19 vaccine. This paper was selected by the journal for a commentary. Her group has also shown that murine Plasmodium spp can survive and replicate within plasmacytoid DC. Their most recent research has now shown how Programmed cell death 1 (PD-1) mediates loss of natural immunity against chronic malaria and memory of the infection.

Abstracts this author is presenting: