Cambodia has made considerable progress in decreasing its malaria burden over the last decade and has set itself a vision to eliminate P.falciparum by 2020 and all forms of malaria-free by 2025. In 2016, the Ministry of Health launched The Malaria Elimination Action Framework (MEAF) 2016-2020, as the guiding document for strategies and interventions in order for Cambodia to successfully reach its P.falciparum elimination goal by 2020. The National Center for Parasitology, Entomology and Malaria Control, Cambodia (CNM) along with its key technical and implementation partners have initiated to mobilize resources in order to reorient the national program toward elimination. With support from Global Fund and other donors, CNM has plans to implement critical components of the elimination program in line with MEAF 2016-2020. Major areas of focus include expansion of community-based testing, effective treatment, efficient targeting of vector control interventions and roll out of a case-based surveillance program including case investigation and foci investigation and response supported by effective monitoring and evaluation methods. As Cambodia continues to reorient its national program to achieve the goal of malaria elimination, the CNM and implementing partners will require additional management support and technical guidance to avoid operational bottlenecks and assure steady progress toward elimination. The Operational Task Force for Malaria Elimination is established to ensure that all activities of CNM and implementing partners supported by financial partners are aligned with MEAF 2016-2020, the operational milestones are being reached as per work plans, and the elimination policies and guidelines are revised, when needed, based on evidence and there is continuous progress toward elimination goals. The task force is supported by three thematic working groups (Surveillance, Diagnosis & Treatment and Vector Control) called on ad-hoc basis to provide specific technical guidance and develop technical guidance documents for the national malaria program.