In 2012 the Global Plan for Insecticide Resistance Management (GPIRM) outlined a series of recommendations to address the growing threat of insecticide resistance in malaria control, including the pre-emptive annual rotation of indoor residual spraying (IRS) products. However, the ability of country programs to rotate IRS products with different modes of action has been impeded by widespread resistance to existing products and the lack of multiple, effective products to use in a rotation strategy. Many IRS programmes have had no choice but to rely on repeated use of a micro-encapsulated formulation of pirimiphos-methyl (Actellic®300 CS) as a last line product for Anopheles control. With the launch of SumiShield®50 WG, a new mode of action “long-lasting” IRS product—and other 3GIRS products to follow—the annual rotation goal outlined in GPIRM is achievable. Examples of rotation strategies will be presented that decision makers can now take to simultaneously prevent resistance through pre-emptive rotation—rotating products prior to evidence of product failure—while also positively influencing the IRS market through reduced market volatility, increased competition, and reduced prices. This new strategic approach to rotation of multiple 3GIRS products within a country helps support resistance prevention best practices, multi-year forecasts, and reduced price through competition. In 2018 several African IRS programmes will implement insecticide resistance prevention and management through the simultaneous use of both available 3GIRS products as part of a sub-national rotation strategy which rotates 3GIRS products every spray campaign. A pre-emptive rotation strategy based on using multiple, effective IRS products, within a country at a district or other operationally feasible administrative unit as appropriate, promises to support resistance prevention best practices; provide increased competition which should promote reduced prices; and facilitate stable, multi-year forecasts of multiple products with different modes of action.