A mathematical model was developed to simulate the METF activities. The model created a synthetic population of individuals clustered within villages. The villages were linked in a similar way to those in the study area in terms of P.falciparum malaria transmission. The purpose of the model was to reproduce the observed decreases in malaria infection, to explore the relative contribution of the activities (early detection and mass drug administration) to that decrease and to simulate alternative designs for both future trials and programmatic implementation.