The remit of ADB’s Regional Malaria and other Communicable Disease Threats Trust Fund (RMTF), established in 2013 with funding from Department for International Development of the United Kingdom and the Department of Foreign Affairs and Trade of the Government of Australia was to support ADB’s developing member countries (DMCs) to develop multi-country, cross-border and multisector responses to urgent malaria and other communicable disease issues. The RMTF has funded a range of projects under six distinct themes: leadership, financing, medicines, information systems, laboratory diagnostics and surveillance, and promotion and prevention. As the fund’s activities came to a close in mid-2018, it became clear that far from being disparate, the results of each theme intersect with each other to create a web of innovative, transformational and–importantly–sustainable outcomes that have strengthened the region’s capacity to eliminate malaria, and in the process become stronger in the face of multiple communicable disease threats in the years ahead. The panel contribution will highlight key achievements of the RMTF, provide more detailed analysis of the results and profile specific projects that serve as examples of the fund’s impact.